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  • Title: Hair cell loss and regeneration after exposure to intense sound in neonatal chicks.
    Author: Henry WJ, Makaretz M, Saunders JC, Schneider ME, Vrettakos P.
    Journal: Otolaryngol Head Neck Surg; 1988 Jun; 98(6):607-11. PubMed ID: 3138621.
    Abstract:
    Neonatal chicks (between 1 and 3 days of age) were exposed to an intense pure tone for 48 hours, then killed immediately after removal from the sound, or 14 days later. Nonexposed age-matched animals served as controls. The inner ear was removed and the auditory receptor organ (the basilar papilla) was prepared for evaluation by scanning electron microscopy. The site of injury on the papilla was described in terms of hair-cell loss and location. The ears with no recovery showed a discrete lesion area, within which there was complete disruption of the hair-cell field and a 35% loss in hair cells. After 14 days' recovery, no hair cell loss could be detected, though the lesion could still be recognized by the disorganization of hair cells in the previously injured area. These data demonstrate hair-cell restoration after severe acoustic injury from intense sound exposure in the neonatal ear.
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