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  • Title: High-titer, high-thermal-amplitude cold autoagglutinin not associated with hemolytic anemia.
    Author: Sniecinski I, Margolin K, Shulman I, Oien L, Meyer E, Branch DR.
    Journal: Vox Sang; 1988; 55(1):26-9. PubMed ID: 3138816.
    Abstract:
    An example of an unusual cold autoagglutinin is reported. The antibody was monoclonal IgMKappa able to fix complement, and, in the presence of albumin, had both a high titer (greater than 4,096 at 4 degrees C) and a wide thermal range (4-37 degrees C). The patient was closely followed over a 3-year period with no evidence of hemolysis ever documented, despite a persistently positive direct antiglobulin test and the presence of the cold autoagglutinin. In contrast to previous reports regarding cold-agglutinin disease, this case demonstrates that in vivo hemolysis is not always associated with cold autoagglutinins that in vitro show a high thermal range in the presence of albumin.
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