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  • Title: In vitro antibody response to influenza virus. I. T cell dependence of secondary response to hemagglutinin.
    Author: Anders EM, Peppard PM, Burns WH, White DO.
    Journal: J Immunol; 1979 Sep; 123(3):1356-61. PubMed ID: 313954.
    Abstract:
    A good secondary IgG response to the hemagglutinin (HA) of influenza virus has been obtained in vitro in Marbrook-type cultures of influenza-primed mouse spleen cell suspensions stimulated with inactivated influenza virus. Anti-HA antibody was quantitated by a solid phase radioimmunoassay (RIA) by using purified HA as substrate. The T dependence of this secondary response was shown by depletion of T cells and reconstitution with a source of primed or unprimed T cells. The help given by T cells primed to the homologous virus was many times greater than that given by unprimed T cells, although the latter was significant. The system described will allow investigation of the specificity requirements of helper T cells engaged in the anti-HA response.
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