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  • Title: The inhibitory effect of methanol on forskolin-activated adenylate cyclase in rat erythrocyte membranes dependent on the state of the guanine nucleotide-binding stimulatory and regulatory protein.
    Author: Takeda O, Yamasaki K, Kohda H, Yamashita A, Kurokawa T, Ishibashi S.
    Journal: J Pharmacobiodyn; 1988 May; 11(5):377-80. PubMed ID: 3139858.
    Abstract:
    Forskolin-activated adenylate cyclase activity in rat erythrocyte membranes was markedly inhibited by methanol in a concentration dependent manner. On the contrary, no change was observed in the basal cyclase activity in the presence of methanol. The methanol inhibition forskolin-activated cyclase activity was protected by the stimulation of Gs in the presence of NaF in a concentration dependent manner. These data indicate that low- and high-affinity binding sites of forskolin in rat erythrocyte membranes have different sensitivities to methanol.
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