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  • Title: Genomic analysis and lactose transporter expression in Kluyveromyces marxianus CCT 7735.
    Author: Paiva LC, Diniz RHS, Vidigal PMP, Mendes TAO, Santana MF, Cerdán ME, González-Siso MI, Silveira WBD.
    Journal: Fungal Biol; 2019 Sep; 123(9):687-697. PubMed ID: 31416588.
    Abstract:
    Kluyveromyces marxianus CCT 7735 has been used to produce ethanol, aromatic compounds, enzymes and heterologous proteins besides assimilates lactose as carbon source. Its genome has 10.7 Mb and encodes 4787 genes distributed in 8 nuclear chromosomes and one mitochondrial. Contrary to Kluyveromyces lactis, which has a unique LAC12 gene (encodes lactose permease), K. marxianus possesses four. The presence of degenerated copies and Solo-LTRs related to retrotransposon TKM close to the LAC12 genes in K. marxianus indicates ectopic recombinations. The Lac12 permeases of K. marxianus and K. lactis are conserved, however the conservation is higher between the copy of the left side of the chromosome three and the unique copy of K. lactis, indicating that this copy is the ancestor. The expression of the four LAC12 genes occurred in aerobiosis and hypoxia. Notably, the high lactose consumption in hypoxia seems to be related to the high expression of the LAC12 genes.
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