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  • Title: Indium-111-oxinate labeled swine platelets and their survival in vivo.
    Author: Zoghbi SS, Thakur ML, Sostman HD, Greenspan RH, Gottschalk A.
    Journal: Lab Anim Sci; 1988 Aug; 38(4):444-7. PubMed ID: 3141679.
    Abstract:
    Since the fibrinolytic system of the swine is close to that of human, the use of a swine model may assume increasing prominence in future studies of thrombosis. Swine platelets were labeled with 111In in a modified Tyrode's solution, suspended in plasma, then injected intravenously into swine. The average radioactivity incorporated into the platelets was 44 +/- 27%. The recovery of labeled platelets at 5 minutes post-injection was 81.7 +/- 5.3%. The platelets retained their label throughout their life span. The survival of 111In-platelets was described by a one component exponential equation, with a life span of 157.9 +/- 25.3 hrs.
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