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  • Title: Efficiency of translation initiation by non-AUG codons in Saccharomyces cerevisiae.
    Author: Clements JM, Laz TM, Sherman F.
    Journal: Mol Cell Biol; 1988 Oct; 8(10):4533-6. PubMed ID: 3141793.
    Abstract:
    The quantitative levels of initiation of protein synthesis at codons other than AUG were determined with a CYC7-lacZ fused gene in the yeast Saccharomyces cerevisiae. AUG was the only codon which efficiently initiated translation, although some non-AUG codons allowed initiation at very low efficiency, below 1% of the normal level. Since translation initiates at codons other than AUG in at least two wild-type genes from eucaryotes, other factors presumably play a role in enhancing the activity of non-AUG codons.
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