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  • Title: Synergistic generation of tumoricidal macrophages by muroctasin and interferon-gamma.
    Author: Nagao S, Sato K, Osada Y.
    Journal: Arzneimittelforschung; 1988 Jul; 38(7A):999-1002. PubMed ID: 3142490.
    Abstract:
    The ability of N2-[(N-acetylmuramoyl)-L-alanyl-D-isoglutaminyl]-N6-stearoyl-L-lysine (MDP-Lys(L18), muroctasin), a synthetic muramyl dipeptide derivative, to generate tumoricidal macrophages was investigated. MDP-Lys(L18) alone at the dose employed, 100 ng/ml, did not activate macrophages, and by combination with interferon-gamma (IFN-gamma), synergistically generated tumoricidal macrophages. Priming by IFN-gamma of macrophages enhanced endocytosis of MDP-Lys(L18) by the macrophages, which must be one of the mechanisms of the synergism. Thus, MDP-Lys(L18) is suggested to be a potent macrophage activator.
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