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  • Title: Selective depression by alfentanil of group III and IV somatosympathetic reflexes in the dog.
    Author: Swenzen GO, Chakrabarti MK, Sapsed-Byrne S, Whitwam JG.
    Journal: Br J Anaesth; 1988 Oct; 61(4):441-5. PubMed ID: 3142510.
    Abstract:
    The effect of alfentanil on sympathetic reflexes evoked by supramaximal electrical stimulation of the radial nerve has been observed in five dogs anaesthetized with alpha-chloralose, paralysed with suxamethonium and artificially ventilated. In five dogs during the infusion of alfentanil at a rate of 20 micrograms kg-1 min-1 the late long latency sympathetic response evoked by unmyelinated fibres (group IV, C) was abolished at a mean dose of 68.8 (SE 2.85) micrograms kg-1. The infusion rate was then increased to 200 micrograms kg-1 min-1 and the early, short latency response evoked by small myelinated fibres (group III, A delta) was eliminated at mean total dose of 809 (SE 72) micrograms kg-1. When the infusion was stopped the group III reflex returned within 1-5 min and recovery to approximately 50% of control for both reflexes occurred within 15-60 min in different preparations. Mean arterial pressure and mean heart rate decreased from 140 (6) mm Hg and 132 (11) beat min-1 to 100 (7) mm Hg and 70 (6) beat min-1, respectively, by the time the group IV response was eliminated; that is, after a mean infusion time of 3.4 min. Thereafter, there was no further cardiovascular depression. Within 3 min of the administration of naloxone 2 mg i.v., the sympathetic reflexes, arterial pressure and heart rate returned to within control values.
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