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  • Title: Effect of parathyroid hormone and parathyroid hormone fragments on the intracellular ionized calcium concentration in an osteoblast cell line.
    Author: van Leeuwen JP, Bos MP, Löwik CW, Herrmann-Erlee MP.
    Journal: Bone Miner; 1988 Jun; 4(2):177-88. PubMed ID: 3142533.
    Abstract:
    In the present study the effect of parathyroid hormone and parathyroid hormone fragments on the intracellular ionized calcium concentration in an osteoblastic cell line (UMR 106-01) is examined. In these cells the intact hormone, bPTH(1-84) and three fragments (bPTH(1-34), hPTH(1-34) and bPTH(3-34) induce an initial increase of the ionized calcium concentration [( Ca2+]i). The increase of the [Ca2+]i due to bPTH(1-84) is more pronounced and of longer duration compared to the increase due to PTH fragments. For two parathyroid hormone fragments with a modified amino acid sequence [( Nle-8,Nle-18,Tyr-34]bPTH(1-34), [Nle-8,Nle-18,Tyr-34]bPTH(3-34], no effect was found. Our observations suggest: (1) a second messenger role for intracellular ionized calcium in the action of bPTH(1-84) in osteoblasts; (2) a functional role for the COOH-terminal part in the action of bPTH(1-84); and (3) the existence of a specific part of the hormone being responsible for the increase of the intracellular ionized calcium concentration.
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