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  • Title: Structure of a polysaccharide from Trichoderma atroviride and its promotion on tanshinones production in Salvia miltiorrhiza hairy roots.
    Author: Wu J, Ming Q, Zhai X, Wang S, Zhu B, Zhang Q, Xu Y, Shi S, Wang S, Zhang Q, Han T, Qin L.
    Journal: Carbohydr Polym; 2019 Nov 01; 223():115125. PubMed ID: 31426969.
    Abstract:
    This study evaluates the chemical structure of a heteropolysaccharide (PSF-W-1) from the endophytic fungus Trichoderma atroviride and its effects on the production of tanshinones in Salvia miltiorrhiza hairy roots. The total carbohydrate content of isolated PSF-W-1 was determined to be 97.72%. PSF-W-1 has a relative molecular weight of 36.13 kDa and contains mannose, glucose and galactose in molar ratios of 1.00:4.86:2.25. Through methylation analysis, IR and NMR, PSF-W-1 was determined to possess a backbone of →4)-β-D-Glcp-(1→6)-α-D-Galp-(1→4)-β-D-Manp-(1→6)-α-D-Galp-(1→ with two side chains β-D-Glcp-(1→4)-β-D-Glcp-(1→ attached to O3 of 1,6-α-D-Galp. Bioactivity tests suggested that PSF-W-1 was responsible for boosting the S. miltiorrhiza hairy root growth and the biosynthesis of dihydrotanshinone I, tanshinone I, tanshinone IIA and cryptotanshinone in hairy roots. According to this study, PSF-W-1 might be utilized as a potent stimulator of tanshinones synthesis.
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