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  • Title: Storage of sialic acid-containing carbohydrates in the placenta of a human galactosialidosis fetus. Isolation and structural characterization of 16 sialyloligosaccharides.
    Author: Van Pelt J, Van Kuik JA, Kamerling JP, Vliegenthart JF, Van Diggelen OP, Galjaard H.
    Journal: Eur J Biochem; 1988 Nov 01; 177(2):327-38. PubMed ID: 3142773.
    Abstract:
    From the placenta of a human fetus with galactosialidosis, detected by prenatal diagnosis, sialyloligosaccharides were isolated by successively gel-permeation chromatography on Bio-Gel P-6, anion-exchange chromatography on Mono Q and high-performance liquid chromatography on Lichrosorb-NH2. 16 sialic acid-containing N-glycosidic N-acetyllactosamine type of structures were identified by sugar analysis and 500-MHz 1H-NMR spectroscopy. The fully sialylated oligosaccharides differ from each other in the type of branching (mono-, di-, tri-, tri'- and tetra-antennary) or sialic acid linkage types (alpha 2-3/alpha 2-6). The isolated carbohydrates, including six novel structures, can be presented as follows (the numerals in a column represents one compound). (formula; see text).
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