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  • Title: Flecainide acetate in the treatment of resistant supraventricular arrhythmias.
    Author: Epstein M, Jardine RM, Obel IW.
    Journal: S Afr Med J; 1988 Dec 03; 74(11):559-62. PubMed ID: 3143159.
    Abstract:
    Thirty-one patients with a variety of supraventricular tachyarrhythmias resistant to conventional anti-arrhythmic therapy were treated with flecainide acetate, a new class Ic antiarrhythmic drug. The mean follow-up period was 7 months. Control was attained in 19 patients (62%) initially, and the long-term success rate was 39%. In 7 of the 19 controlled patients the drug was subsequently discontinued because of major side-effects, which included negative inotropism and pro-arrhythmia. The mechanisms and implications of these side-effects are reviewed.
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