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  • Title: Visible-Light-Initiated One-Pot, Three-Component Synthesis of 2-Amino-4H-pyran-3,5-dicarbonitrile Derivatives.
    Author: Zhang M, Chen MN, Li JM, Liu N, Zhang ZH.
    Journal: ACS Comb Sci; 2019 Oct 14; 21(10):685-691. PubMed ID: 31433619.
    Abstract:
    A novel approach for the visible-light-initiated synthesis of 2-amino-4H-pyran-3,5-dicarbonitrile derivatives via a one-pot, three-component reaction of aldehydes or isatins, malononitrile, and α-cyano ketones has been developed. The reaction was carried out at room temperature in ethanol/water to give the corresponding products with a wide range of functional groups in high yields. This process did not require any additives or chromatographic separation and could be applied for gram-scale synthesis.
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