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  • Title: An artificial intelligence approach to the study of the structural moieties relevant to drug-receptor interactions in aldose reductase inhibitors.
    Author: Klopman G, Buyukbingol E.
    Journal: Mol Pharmacol; 1988 Dec; 34(6):852-62. PubMed ID: 3143909.
    Abstract:
    The computer-automated structure evaluation program has been used to study 482 compounds relevant to the inhibition of the aldose reductase enzyme. Major activating/inactivating fragments were generated automatically. The significance of these molecular descriptors with respect to the activity of the compounds is discussed.
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