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  • Title: Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells.
    Author: Moreau JF, Donaldson DD, Bennett F, Witek-Giannotti J, Clark SC, Wong GG.
    Journal: Nature; 1988 Dec 15; 336(6200):690-2. PubMed ID: 3143918.
    Abstract:
    Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine M1 myeloid leukaemia cell line. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine interleukin-3-dependent leukaemic cell line, DA-la (refs 3-5). HILDA proved to be identical to LIF. The demonstration that the differentiation factor LIF will also serve as a growth factor for at least one myeloid leukaemic cell line provides further evidence that the distinction between growth-promoting and differentiation-inducing activities are largely determined by the target cell type.
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