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  • Title: Auer rod-like inclusions in the cytoplasm of B-cell lymphoma cells with bone marrow infiltration.
    Author: Gao Z, Cui F, Liu M, Guo Y, Hu Y, Shi M.
    Journal: Exp Hematol; 2019 Sep; 77():6-11. PubMed ID: 31442465.
    Abstract:
    Auer rod-like inclusions are rarely seen in B-cell neoplasms patients. Here, we present a case of B-cell lymphoma with Auer rod-like inclusions in lymphoma cells. By light and transmission electron microscopy, these structures closely resembled Auer rods which were found in acute myeloid leukemia. The Auer rod-like inclusions were negative for cytochemical staining of MPO, α-naphthyl acetate esterase, and periodic acid-Schiff. Immunostaining and flow cytometric analysis confirmed monoclonal Kappa-positive malignant lymphocytes. Interestingly, the Auer rod-like inclusions exhibited diverse ultrastructural features, which ranged from fusiform, to needle-shape, to round, to crystalline cuboid, to long rod, to short rod and others; some were membrane structures, some membrane-free dense structures, and some lamellar structures. The patient was diagnosed with B-cell lymphoma with bone marrow infiltration.
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