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  • Title: The metabolism and pharmacokinetics of fleroxacin in healthy subjects.
    Author: Griggs DJ, Wise R, Kirkpatrick B, Ashby JP.
    Journal: J Antimicrob Chemother; 1988 Oct; 22 Suppl D():191-4. PubMed ID: 3144537.
    Abstract:
    A 400 mg dose of fleroxacin was administered orally to six healthy male volunteers. Concentrations of fleroxacin and the N-demethyl and N-oxide metabolites were determined in serum and urine by HPLC. The serum metabolite levels were negligible. The N-oxide metabolite was measured in the serum of five subjects but did not exceed 4% of the corresponding fleroxacin level. N-demethyl fleroxacin was not detected (less than 0.1 mg/l). The urinary recovery of fleroxacin was 49.5% over 72 h; the N-demethyl and N-oxide metabolites accounted for 6.9% and 5.7%, respectively, of the administered dose.
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