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  • Title: Valproate in the treatment of rapid-cycling bipolar disorder.
    Author: McElroy SL, Keck PE, Pope HG, Hudson JI.
    Journal: J Clin Psychopharmacol; 1988 Aug; 8(4):275-9. PubMed ID: 3145291.
    Abstract:
    Six consecutive patients with rapid-cycling bipolar disorder, refractory or only minimally responsive to treatment with lithium salts and neuroleptics, including five also refractory to carbamazepine, all demonstrated a moderate or marked response to the anticonvulsant valproate. These observations suggest that valproate may represent a promising treatment alternative in this often treatment-resistant form of bipolar disorder.
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