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  • Title: Accuracy of a central mass spectrometer system at high respiratory frequencies.
    Author: Scamman FL.
    Journal: J Clin Monit; 1988 Jul; 4(3):227-9. PubMed ID: 3145330.
    Abstract:
    We have shown that in a laboratory setting the long lengths of sampling catheters necessary to access a central mass spectrometer restrict the high-frequency response of the system. Reported here are the results from a clinically operating Perkin-Elmer Advantage system. The sampling catheter was 50 meters long and the sampling flow was 240 ml/min. Rapid changes in carbon dioxide concentration were created by an electronically operated solenoid valve switching between 6.94% CO2 in 50% O2 balance N2 and 100% O2. The frequency of this simulated breathing was varied between 10 and 100 breaths/min with the ratio of inspiration to expiration fixed at 1:2. Data were taken from the terminal in the operating room. Errors greater than 5% of the true value occurred at 35 breaths/min for the indicated inspired concentration and 73 breaths/min for the indicated expired concentration. For critical situations in which respiratory frequencies exceed 40 breaths/min, a centrally located mass spectrometer may not be adequate for measuring CO2 because of errors introduced by the long sampling catheters.
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