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  • Title: A biotinylated ruthenium(ii) photosensitizer for tumor-targeted two-photon photodynamic therapy.
    Author: Li J, Zeng L, Xiong K, Rees TW, Jin C, Wu W, Chen Y, Ji L, Chao H.
    Journal: Chem Commun (Camb); 2019 Sep 10; 55(73):10972-10975. PubMed ID: 31453611.
    Abstract:
    Platinum-resistant cancer cells are sensitive to changes in the levels of reactive oxidative species (ROS). Herein, we design a biotin-modified Ru(ii) complex as a photosensitizer (denoted as Ru-Biotin). Ru-Biotin can selectively target cancer cells and produce vast amounts of singlet oxygen under two-photon excitation at 820 nm leading to cell apoptosis. Ru-Biotin is therefore an excellent candidate to overcome platinum resistance via two-photon photodynamic therapy.
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