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  • Title: Visible-light-mediated defluorinative cross-coupling of gem-difluoroalkenes with thiols.
    Author: Wang J, Huang B, Yang C, Xia W.
    Journal: Chem Commun (Camb); 2019 Sep 21; 55(74):11103-11106. PubMed ID: 31461099.
    Abstract:
    Here we report a visible-light-mediated monofluoroalkenylation through defluorinative cross-coupling of gem-difluoroalkenes with aryl, benzyl, and alkyl thiols. This novel strategy provides facile and efficient access to tri/tetra-substituted monofluoroalkenes under mild reaction conditions with good functional group tolerance. Late-stage modification of natural products indicated the synthetic potential of this S-H monofluoroalkenylation process.
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