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  • Title: Presence of antibody to A- and B-transferases in minor incompatible bone marrow transplant.
    Author: Barbolla L, Mojena M, Boscá L.
    Journal: Br J Haematol; 1988 Dec; 70(4):471-6. PubMed ID: 3146341.
    Abstract:
    The contribution of the bone marrow to plasma A- or B-transferase activities has been studied in patients who underwent incompatible bone marrow transplantation (BMT). As deduced from major incompatibility (group O recipient/A donor), the contribution of the marrow to these plasma activities was c. 5-10% of the total activity. In cases of minor incompatible transplants (A recipient/O donor), normal plasma activity was present in two patients, while no activity was found in a further two in whom a potent antitransferase was detected. The antibody inhibited both A- and B-transferase activities to a high titre. The patients in whom this antibody arose exhibited severe graft-versus-host disease.
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