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  • Title: Linc-PINT acted as a tumor suppressor by sponging miR-543 and miR-576-5p in esophageal cancer.
    Author: Zhang L, Chen J, Wang L, Chen L, Du Z, Zhu L, Cui M, Zhang M, Song L.
    Journal: J Cell Biochem; 2019 Dec; 120(12):19345-19357. PubMed ID: 31464068.
    Abstract:
    This manuscript aimed to investigate linc-PINT's role as a tumor suppressor and its downstream microRNAs (miRNAs) in esophageal cancer. Log-rank, Cox, and nomogram were used for survival analysis. Quantitative real-time polymerase chain reaction was used to evaluate the expression. Cell counting kit-8 was used for proliferation tests. As for in vivo experiments, low expression of linc-PINT was associated with better prognosis; besides, the nomogram indicated that linc-PINT, miR-543, and miR-576-5p served well in predicting the survival rate. As for the in vitro experiments, linc-PINT could directly regulate miR-543 and miR-576-5p to inhibit the proliferation of Eca-109 cell line. In conclusion, linc-PINT-miR-543/miR-576-5p pathway could predict the prognosis and provide novel therapeutic targets for esophageal cancer.
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