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  • Title: Nonamyloidotic monoclonal immunoglobulin deposits lack amyloid P component.
    Author: Gallo G, Picken M, Frangione B, Buxbaum J.
    Journal: Mod Pathol; 1988 Nov; 1(6):453-6. PubMed ID: 3146753.
    Abstract:
    Deposits in tissues from 13 patients with amyloid, 8 with monoclonal light chain or light and heavy chain deposition disease, and 2 with both amyloid and nonamyloidotic light chain deposits of the same isotype were examined in parallel for the presence of amyloid P component by immunofluorescence and/or immunoperoxidase methods. Amyloid P component was detected in the amyloid but not the nonamyloid deposits, even in the 2 individuals in whom both types of deposits were present, indicating a specific relationship between the amyloid P component and the amyloid fibrils.
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