These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Computational modeling of the effects of EEG volume conduction on functional connectivity metrics. Application to Alzheimer's disease continuum.
    Author: Ruiz-Gómez SJ, Hornero R, Poza J, Maturana-Candelas A, Pinto N, Gómez C.
    Journal: J Neural Eng; 2019 Oct 29; 16(6):066019. PubMed ID: 31470433.
    Abstract:
    OBJECTIVE: The aim of this study was to evaluate the effect of electroencephalographic (EEG) volume conduction in different measures of functional connectivity and to characterize the EEG coupling alterations at the different stages of dementia due to Alzheimer's disease (AD). APPROACH: Magnitude squared coherence (MSCOH), imaginary part of coherence (iCOH), lagged coherence (lagCOH), amplitude envelope correlation (AEC), synchronization likelihood (SL), phase lag index (PLI), phase locking value (PLV), and corrected imaginary PLV (ciPLV) were applied to: (i) synthetic signals generated with a Kuramoto-based model of several coupled oscillators; and (ii) a resting-state EEG database of real recordings from 51 cognitively healthy controls, 51 mild cognitive impairment (MCI) subjects, 51 mild AD (AD mil ) patients, 50 moderate AD (AD mod ) patients, and 50 severe AD (AD sev ) patients. MAIN RESULTS: Our results using synthetic signals showed that PLI was the least affected parameter by spurious influences in a simulated volume conduction environment. Results using real EEG recordings showed that spontaneous activity of MCI patients is characterized by a significant coupling increase in the [Formula: see text] band. As dementia progresses, this increase in the [Formula: see text] band became more pronounced, and a significant widespread decrease in [Formula: see text] band appeared at the last stage of dementia. SIGNIFICANCE: Our results revealed that the estimation of functional EEG connectivity using PLI could reduce the bias introduced by the spurious influence of volume conduction, and it could increase the insight into the underlying brain dynamics at different stages of the AD continuum.
    [Abstract] [Full Text] [Related] [New Search]