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  • Title: Antibacterial stilbenes from the tubers of Bletilla striata.
    Author: Jiang S, Chen CF, Ma XP, Wang MY, Wang W, Xia Y, Zhang N, Wu MK, Pan WD.
    Journal: Fitoterapia; 2019 Oct; 138():104350. PubMed ID: 31473333.
    Abstract:
    Three new bibenzyl derivatives (bletstrins A-C, 1-3), including two bibenzyls that have hydroxyl-substituted chiral centers on the aliphatic bibenzyl bridge, along with eighteen known stilbenoids (4-21) were isolated from the tubers of Bletilla striata. The structures of new compounds were elucidated by the use of 1D/2D NMR spectroscopic data. The absolute configurations of bletitrins A and B were determined by optical rotation value. Compounds 13-16 were isolated from the Orchidaceae for the first time. Most of the isolated compounds were evaluated for their antibacterial activities against three gram-positive bacterial strains and one gram-negative bacterial strain. Compounds 4, 10, 12, 14, 15, 16 and 18 showed potent inhibitory activities, with MICs of (6-52 μg/mL) against S. aureus ATCC 6538.
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