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  • Title: Evaluation of pituitary structures and lesions with turbo spin-echo diffusion-weighted imaging.
    Author: Khant ZA, Azuma M, Kadota Y, Hattori Y, Takeshima H, Yokogami K, Watanabe T, Enzaki M, Nakaura T, Hirai T.
    Journal: J Neurol Sci; 2019 Oct 15; 405():116390. PubMed ID: 31476623.
    Abstract:
    BACKGROUND AND PURPOSE: Turbo spin-echo diffusion-weighted imaging (TSE-DWI) has not been used for evaluating pituitary lesions. We compared the usefulness of TSE-DWI and echo-planar (EP)-DWI for assessing normal pituitary structures and lesions. MATERIALS AND METHODS: Our study included 41 consecutive patients (27 pituitary adenomas, 8 Rathke's cleft cysts, 4 craniopharyngiomas, 1 germinoma, 1 pituitary metastasis) who underwent conventional pre- and post-contrast magnetic resonance imaging (MRI) and TSE- and EP-DWI at 3T. Two observers independently performed qualitative assessment of normal pituitary structures and lesions on sagittal DWI and apparent diffusion coefficient (ADC) maps. One observer recorded ADC values of normal brain structures and pituitary lesions. Kappa (κ) statistics, Wilcoxon signed-rank test, intraclass correlation coefficient, Bland-Altman analysis, Pearson correlation coefficient and independent t-test were used for statistical analysis. RESULTS: Interobserver agreement for qualitative evaluations was good to excellent (κ = 0.65-1.0). On both DWI and ADC maps, visualization of the pituitary gland, of the spatial relationship between the lesion and its normal surroundings, and the whole image quality were significantly better on TSE- than EP sequences (p < .01). In normal brain structures, the ADC value on TSE- and EP-sequences was significantly correlated (r = 0.6979, p < .05). The TSE-ADC value was significantly lower for pituitary adenomas than craniopharyngiomas (p < .05). CONCLUSIONS: For the evaluation of normal pituitary structures and lesions, TSE-DWI is more useful than EP-DWI. The TSE-ADC value may help to differentiate between pituitary adenoma and craniopharyngioma.
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