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  • Title: Chemical constituents from Ginkgo biloba leaves and their cytotoxicity activity.
    Author: Shu P, Sun M, Li J, Zhang L, Xu H, Lou Y, Ju Z, Wei X, Wu W, Sun N.
    Journal: J Nat Med; 2020 Jan; 74(1):269-274. PubMed ID: 31493217.
    Abstract:
    One novel neoligan glucoside, Ginkgoside B (1), and one new glucose ester, 6-O-(4-hydroxyhydrocinnamoyl)-D-glucopyranose (2), along with nine known compounds (3-11) were isolated from the ethanol extract of Ginkgo biloba leaves. Their structures were elucidated by combination of spectroscopic analyses and alkaline methanolysis. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction. All the isolated compounds were evaluated for their cytotoxicity activities, and compound 11 exhibited IC50 values of 36.20 and 58.95 μM against 5637 and HeLa cell lines, respectively.
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