These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Lysosome-targeting turn-on red/NIR BODIPY probes for imaging hypoxic cells.
    Author: Kong X, Di L, Fan Y, Zhou Z, Feng X, Gai L, Tian J, Lu H.
    Journal: Chem Commun (Camb); 2019 Sep 24; 55(77):11567-11570. PubMed ID: 31495830.
    Abstract:
    A small series of fluorescent lysosome-targeting probes based on the BODIPY fluorophore and containing morpholine and nitro groups were rationally designed. These probes emitted light from green to NIR wavelengths, and provided specificity for imaging the lysosomes of hypoxic cells. The electron-withdrawing nitrophenyl group at the meso position was found to lead to highly efficient nonradiative decay of the S1 state, and hence a recovery of fluorescence when reduction of the nitro group occurred under hypoxic conditions.
    [Abstract] [Full Text] [Related] [New Search]