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  • Title: [Mitomycin C induced structural changes in heterochromatic regions of human chromosomes 1, 9, 16 and Y].
    Author: Malygina NA, Remizova OG, Akuf'ev AP.
    Journal: Tsitologiia; 1988 Nov; 30(11):1350-4. PubMed ID: 3149811.
    Abstract:
    Aberrations and variations in the heterochromatic blocks of chromosomes 1, 9, 16 and Y were found under the influence of mitomycin C in cultured lymphocytes of peripheral human blood. Lymphocytes were cultured during 96 hours, mitomycin C in final concentration of 0.3 mkg/ml was present in the culture during the latest 24 hours of culturing. Different changes in the heterochromatic regions of chromosomes were found in approximately 30% of cells: in 6.3% of cells mitotic chiasmata were indicated. In 9.5% of cells isolocus breaks were observed in heterochromatic region of chromosome 1 in segment 1q11. In the latter case this may be a fragile site detected under the influence of mitomycin C on the lymphocytes.
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