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  • Title: Electrophoretic deposition of GHK-Cu loaded MSN-chitosan coatings with pH-responsive release of copper and its bioactivity.
    Author: Ning C, Jiajia J, Meng L, Hongfei Q, Xianglong W, Tingli L.
    Journal: Mater Sci Eng C Mater Biol Appl; 2019 Nov; 104():109746. PubMed ID: 31500015.
    Abstract:
    Despite the fact that titanium has been widely applied in the replacement of bone defects, prosthesis failure still occurred because of the lack of adequate bone-bonding ability and the incidence of post-surgery infections. Concentration-dependent effects of therapeutic copper ions (Cu2+) for antibacterial and osteogenic activity have been well-established in the field of biomedical application. In this study, we prepared mesoporous silica nanoparticles (MSN) and MSN-COOH with uniform sphere size (~100 nm) and developed multifunctional chitosan coatings loaded with MSN@GHK-Cu (glycyl-L-histidyl-l-lysine-Cu2+) as a suitable strategy by electrophoretic deposition (EPD). The microstructure and composition of the coating were comprehensively characterized by using SEM, XRD, FTIR, and TEM, respectively. The functional activity of Cu2+ releasing from the surface was dependent on the pH value of the titanium surface. Through the controllable release of Cu2+, the coating achieved not only inhibited adhesion of bacteria but also had good cytocompatibility. The coating based on EPD technique could be considered as a promising surface modification approach for the controlled delivery in situ of drug or other biomolecules.
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