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  • Title: Immunoregulation in human schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms.
    Author: Colley DG, Parra JC, Montesano MA, Lima M, Nascimento E, Doughty BL, Goes A, Gazzinelli G.
    Journal: Mem Inst Oswaldo Cruz; 1987; 82 Suppl 4():105-9. PubMed ID: 3151084.
    Abstract:
    Anti-idiotypic (anti-Id) T cells from schistosomiasis patients or former patients proliferate upon exposure to polyclonal or monoclonal anti-soluble egg antigen (SEA) antibodies. Chloroquine does not inhibit, the response, which is induced by F(ab')2 (but not soluble Fab) fragments of these antibodies. Purified T cells from former patients require macrophages or exogenous IL-1 to respond to anti-SEA Ids and can respond to matrix-bound Fab fragments in the presence of IL-1. These anti-Id T cells recognize the Ids directly. Chronic schistosomiasis patients immunoregulate the production of a non-IL-2 lymphokine that stimulates IL-2 receptor expression on resting T cells. This regulation is reversed upon chemotherapeutic cure.
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