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  • Title: Paranasal sinus invasion suggested T4 classification of patients of nasopharyngeal carcinoma: A two-center retrospective investigation.
    Author: Wu L, Zhuo S, Zeng W, Liang S, Wang S, Cui C, Zhou J, Ruan G, Xu S, Wang L, Huang L, Liu L, Li H.
    Journal: Head Neck; 2019 Dec; 41(12):4088-4097. PubMed ID: 31518030.
    Abstract:
    BACKGROUND: To investigate the prognostic significance of paranasal sinus invasion in nasopharyngeal carcinoma (NPC) patients. METHODS: Patients with NPC after intensity-modulated radiotherapy from 2010 to 2013 were identified (n = 1225). Clinical features and magnetic resonance images were analyzed. RESULTS: Paranasal sinus invasion was identified in 182/1225 patients (14.9%). Multivariate analysis showed that paranasal sinus invasion was an independent factor for overall survival, progression-free survival, distant metastasis-free survival, and local recurrence-free survival (P < .05 for all). T3 NPC patients with paranasal sinus invasion had a poorer prognosis than those without (P < .05), and there was no significant survival difference compared with T4 patients, regardless of involvement of inner structures (P > .05 for all). Upgrading NPC with paranasal sinus invasion to T4 disease achieved better predictive abilities. CONCLUSIONS: Paranasal sinus invasion is an independent prognostic factor for NPC. It may be appropriate to upgrade the T classification.
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