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  • Title: MAO activity, serotonin metabolism and aggregation of platelets from migraine patients. A preliminary study.
    Author: Kovács K, Tóthfalusi L, Hermán F, Magyar K.
    Journal: Pol J Pharmacol Pharm; 1988; 40(6):691-5. PubMed ID: 3152004.
    Abstract:
    Platelets of migraine patients showed abnormal behavior such as hyperaggregability and reduced monoamine oxidase activity (MAO). We measured the MAO activity, serotonin (5-HT) content and release, adenosine diphosphate (ADP)-induced aggregation, and the prostacyclin (PGI2) antiaggregatory effect using the same sample of platelets from migraine patients to find out if these characteristics are intercorrelated. A significant correlation between MAO activity and sensitivity to PGI2 was found.
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