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  • Title: [Ultrastructure and antigens in differentiation of thymus lymphocytes in human embryogenesis].
    Author: Raĭtsina SS, Kalinina II.
    Journal: Biull Eksp Biol Med; 1979 Oct; 88(10):470-3. PubMed ID: 315244.
    Abstract:
    Thymus lymphocytes of 7--8-week human embryos have nuclei of irregular form with 1--3 distinct nucleoli characterized by absence of compact chromatin or heterchromatin. The electron-dense cytoplasm of these cells contains polysomes and an insignificant number of mitochondria. No receptors to sheep red blood cells and T antigen are revealed on their surface. In 11--12-week human embryos one can observe a decrease in the size of thymus lymphocytes, appearance of heterochromatin in their nuclei and receptors to sheep red blood cells (79%), and T antigen (60%) on the cell surface. Subsequently the quantity of compact chromatin in thymus lymphoid cells increases, and the cells acquire definitive properties and structure.
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