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  • Title: Parenteral Nutrition Drug Shortages: A Single-Center Experience With Rapid Process Change.
    Author: Nystrom EM, Bergquist WJ, Wieruszewski PM, McMahon MM, Barreto EF.
    Journal: JPEN J Parenter Enteral Nutr; 2019 Jul; 43(5):583-590. PubMed ID: 31531869.
    Abstract:
    Disruptions in the medication supply chain and consequent drug product shortages, including shortages of parenteral products used for parenteral nutrition (PN) compounding, have become an increasingly common occurrence. The amino acid solution shortage that resulted from the devastating impact of Hurricanes Maria and Irma on manufacturing facilities in Puerto Rico in 2017 necessitated a rapid, coordinated shift from use of compounded PN to commercial multichamber-bag PN (MCB-PN) at our hospitals. We describe our experience operationalizing this intervention via a framework that may be adapted for addressing other drug product shortages to promote rapid yet safe use of therapeutic alternatives.
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