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  • Title: ω-3 PUFAs Alleviate High-Fat Diet-Induced Circadian Intestinal Microbes Dysbiosis.
    Author: Gui L, Chen S, Wang H, Ruan M, Liu Y, Li N, Zhang H, Liu Z.
    Journal: Mol Nutr Food Res; 2019 Nov; 63(22):e1900492. PubMed ID: 31533200.
    Abstract:
    SCOPE: Published data support that fish oil and algae oil rich in ω-3 polyunsaturated fatty acids (PUFAs) protect against hyperlipidemia in mice. This study is aimed to explore the effects of fish oil and algae oil on high-fat diet (HFD) induced circadian intestinal microbes dysregulation. METHODS AND RESULTS: Male C57BL/6 mice are randomly divided into four groups, which are fed a normal chow diet (CON), a HFD, a HFD supplemented with fish oil (FO), and a HFD supplemented with algae oil (AO), respectively, for 12 weeks. At the end of the experiment, mice are sacrificed at 12 h intervals with the first one at zeitgeber time 0 (ZT0) and the second at zeitgeber time 12 (ZT12). FO and AO groups ameliorate diet-induced hyperlipidemia. The relative abundance of certain genera is improved in FO and AO groups according to 16S rRNA gene sequencing. The short-chain fatty acids (SCFAs) producing bacteria Butyricimonas and some of the genera in the Lachnospiraceae recover to the normal circadian rhythm in both FO and AO groups. CONCLUSION: The data show that FO and AO alleviate circadian gut microbiota dysregulation in mice caused by HFD, and support the further investigation of ω-3 PUFAs as a dietary intervention strategy for the prevention of hyperlipidemia.
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