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  • Title: New 8-Hydroxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae).
    Author: Chen YY, Fang LS, Chen YH, Peng BR, Su TP, Huynh TH, Lin FY, Hu CC, Lin NC, Wen ZH, Chen JJ, Lee CY, Wang JW, Sung PJ.
    Journal: Mar Drugs; 2019 Sep 14; 17(9):. PubMed ID: 31540107.
    Abstract:
    Three new 8-hydroxybriaranes-fragilides R-T (1-3) were obtained from a sea whip gorgonian coral Junceella fragilis. The structures of briaranes 1-3 were elucidated by using spectroscopic methods, including 1D (1H and 13C NMR), 2D (COSY, HSQC, HMBC, and NOESY experiments) NMR studies, and (+)-HRESIMS. Fragilides S and T (2 and 3) are the only briaranes known to possess 8α-hydroxy and 17β-methyl groups, respectively. Briarane 2 exerted an inhibition effect on iNOS release from RAW264.7; a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.
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