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  • Title: Congenital fibrinogen disorders with repeated thrombosis.
    Author: Zhang X, Zhang C, Wang B, Chen N, Sun G, Guo X.
    Journal: J Thromb Thrombolysis; 2020 Feb; 49(2):312-315. PubMed ID: 31542854.
    Abstract:
    Congenital dysfibrinogenemia is characterized with undetectable or low fibrinogen level by Clauss assay complicated by bleeding and/or thrombosis. These may lead to a diagnostic problem to some clinicians unfamiliar with this disease. We reported a case of congenital dysfibrinogenemia manifested as hemorrhage, repeated thrombosis, low fibrinogen levels through Clauss assay and but normal levels of fibrinogen through PT-derived tests. In conclusion, to patients with thrombosis complicated by decreased fibrinogen level, clinicians and laboratory physicians should be alert to the possibility of congenital dysfibrinogenemia.
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