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  • Title: A new antibacterial tirucallane from Walsura trichostemon roots.
    Author: Suchaichit N, Kanokmedhakul K, Promgool T, Moosophon P, Chompoosor A, P Suchaichit N, Kanokmedhakul S.
    Journal: Nat Prod Res; 2021 Aug; 35(16):2799-2803. PubMed ID: 31544521.
    Abstract:
    Phytochemical investigation of the roots of Walsura trichostemon, a Thai medicinal plant, provided a new tirucallane, 3-epimesendanin S 12-acetate (1), together with four known compounds, 3-epimesendanin S (2), meliasenin G (3), β-sitosterol (4) and β-sitosterol glucoside (5). Their structures were characterized by intensive spectroscopy including 1 D and 2 D NMR, UV, IR and MS spectrometric analysis. The isolated compounds were evaluated for antibacterial and acetylcholinesterase inhibitory activities. Compounds 1-2 showed antibacterial activity against Bacillus cereus and Bacillus subtilis with MIC values ranging from 16-128 μg/mL. In addition, compound 3 was active against Pseudomonas aeruginosa and Escherichia coli with MIC values of 64 and 128 μg/mL, respectively.
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