These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Non-stick hemostasis hydrogels as dressings with bacterial barrier activity for cutaneous wound healing.
    Author: Pan H, Fan D, Duan Z, Zhu C, Fu R, Li X.
    Journal: Mater Sci Eng C Mater Biol Appl; 2019 Dec; 105():110118. PubMed ID: 31546362.
    Abstract:
    Wound recovery is a complex process which is influenced by many factors. Therefore, dressings with multi-functions can greatly promote wound healing. In this study, a series of multifunctional PVA/HLC/SA composite hydrogels with air permeability, anti-protein absorption, bacterial barrier property and hemostasis activity were synthesized in the prospect of producing wound dressings by repeated freeze-thawing of poly (vinyl alcohol), Human-like collagen (HLC) and sodium alginate (SA) with Tween80 added as porogen. Infrared spectrometry (FT-IR) and scanning electron microscope (SEM) clarified its homogeneous porous and interconnected internal structures. In addition, the hydrogels were characterized statistically and in vivo full-thickness defects in rabbit was done to verify their effect on wound healing. Two of the hydrogels (gel 2 and gel 3) showed excellent water vapor transmission rate (2420.97 and 2798.09 g·cm-2·d-1)，their swelling ratio were 1427.44 and 2308.24% respectively, worked together with hemostasis property (hemostasis time of gel 2 and gel 3 were 30.55 and 17.33 s respectively), anti-protein absorption and bacterial barrier activity, greatly promoted the full-thickness wound healing in rabbit, wounds of the hydrogel dressing groups took only 10 days to heal, while the control groups need 13-15 days. In a whole, the results facilitate the use of provided hydrogel dressings as ideal wound dressings.
    [Abstract] [Full Text] [Related] [New Search]