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  • Title: Lysosomal isoenzyme profiles used to classify a case of acute undifferentiated leukaemia.
    Author: Eden OB, Darbyshire P, Simpson RM, Besley GT, Moss S, Gentle T.
    Journal: Br J Haematol; 1985 Jan; 59(1):109-14. PubMed ID: 3155960.
    Abstract:
    Lysosomal enzyme activities and isoenzyme profiles were measured in lymphoid and non-lymphoid leukaemic cells from childhood patients. High activities, especially of beta-hexosaminidase and alpha-mannosidase, were associated with leukaemic cells of myeloid or monocytic origin. Leukaemic cells from two children with acute myeloid leukaemia had a relative reduction in the B isoenzyme of beta-hexosaminidase activity, whereas in patients with non T, non B cell acute lymphoblastic leukaemia, intermediate beta-hexosaminidase isoenzymes were expressed. A patient is described on whom conventional marker studies were either negative or equivocal, but lysosomal enzyme markers were consistent with a myeloid leukaemia. This observation was supported by the clinical course of this patient.
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