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  • Title: Potentiation of beta-endorphin effects by proglumide in rats.
    Author: Katsuura G, Itoh S.
    Journal: Eur J Pharmacol; 1985 Jan 08; 107(3):363-6. PubMed ID: 3156751.
    Abstract:
    The effects of proglumide, a cholecystokinin (CCK) receptor antagonist, on the analgesia and catalepsy induced by beta-endorphin were investigated in rats. Proglumide itself produced a slight analgesia but no catalepsy. Combined intracerebroventricular administration of beta-endorphin and proglumide produced marked potentiation of the analgesic and cataleptic effects of beta-endorphin. The results suggest that endogenous CCK may have an antagonistic effect on the actions of beta-endorphin in the brain.
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