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  • Title: Sister chromatid exchanges induced by sarcolysine in human lymphocytes in vitro.
    Author: Moraru I, Georgian L, Roman IC, Drăghicescu T.
    Journal: Morphol Embryol (Bucur); 1985; 31(1):5-7. PubMed ID: 3157053.
    Abstract:
    The effect of three concentrations of sarcolysine (0.5 micrograms/ml, 1 microgram/ml and 2 micrograms/ml) on the sister chromatid exchanges (SCE) was investigated in human lymphocytes in vitro. A dose related increase in SCEs frequencies was observed after sarcolysine administration and also a delayed development of cell cycle has been induced by the two last concentrations. The variation range of SCEs per cell was dose-dependent and it was considered to represent the acquired genetic instability induced by the drug.
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