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  • Title: In vitro study of Fc-receptor function in autoimmune diseases.
    Author: Roccatello D, Bensa JC, Coppo R, Rollino C, Diaz M, Martina G, Piccoli G.
    Journal: Immunol Lett; 1985; 9(1):53-6. PubMed ID: 3157644.
    Abstract:
    A simple test for studying in vitro Fc-receptor function of mononuclear phagocytes is described. Immune phagocytosis is analyzed as a dynamic phenomenon by using nearly pure suspensions of monocytes incubated for diverse times with autologous erythrocytes sensitized with highly purified IgG. In a series of normal volunteers and patients with vasculitis a strict correlation has been found between this in vitro assay and the measure of splenic clearance of IgG-coated red blood cells (RBC), the classical approach for studying in vivo macrophage Fc-receptor function by using sodium chromate 51Cr as tag. The use of this in vitro assay appears to be valuable mainly in cases requiring repeated measurements of Fc-receptor function for monitoring the course of disease or the effects of therapy.
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