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  • Title: Characterization of the role of mononuclear cell subpopulations in the in vitro lymphocyte proliferation assay.
    Author: Gehrz RC, Knorr SO.
    Journal: Clin Exp Immunol; 1979 Sep; 37(3):551-7. PubMed ID: 315848.
    Abstract:
    Purified human mononuclear cell subpopulations have been evaluated in the in vitro lymphocyte proliferation assay. Monocyte-depleted mononuclear cells had reduced or absent responses to mitogens and antigens which could be restored to the original mononuclear cell response by addition of purified plastic adherent cells. Purified T lymphocytes obtained by density gradient centrifugation of E-rosette-forming cells demonstrated low but significant proliferative responses to mitogens, but no significant response to antigens. The addition of monocytes potentiated the response of purified T cells to mitogens and antigens, but did not fully reconstitute the original mononuclear cell response unless non-T lymphocytes were also present. It is concluded that mononuclear cell proliferation represents a complex mechanism of cellular interaction involving multiple subpopulations of cells.
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