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  • Title: [The Papillon-Lefevre syndrome (keratosis palmoplantaris with periodontopathy). Treatment with etretinate].
    Author: Wehrmann W, Traupe H, Happle R.
    Journal: Hautarzt; 1985 Mar; 36(3):173-5. PubMed ID: 3158626.
    Abstract:
    The Papillon-Lefèvre syndrome is an autosomal recessive gene defect characterized by transgredient palmoplantar hyperkeratosis and periodontopathia leading to loss of the teeth. The syndrome is described in a 28-year-old man who had lost all of his teeth at the age of 10 years. Treatment with etretinate resulted in a marked improvement of the palmar and plantar skin lesions.
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