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  • Title: 125I-labelled human interferons alpha, beta and gamma: comparative receptor-binding data.
    Author: Merlin G, Falcoff E, Aguet M.
    Journal: J Gen Virol; 1985 May; 66 ( Pt 5)():1149-52. PubMed ID: 3158718.
    Abstract:
    Binding of 125I-labelled human recombinant DNA interferons (IFNs) alpha-2, beta and gamma was compared on various human lymphoid cells and embryonic fibroblasts. While binding constants were within an order of magnitude for all three interferons (10(-10) to 10(-9) M), no competition was observed between IFN-gamma on the one hand and IFN-alpha 2 and IFN-beta on the other. However, consistent with previous reports, IFN-alpha 2 and IFN-beta competed for presumably common receptors. Depending on the cell type, binding sites for IFN-gamma were expressed in different numbers compared to those for IFN-alpha 2 and IFN-beta. These direct comparative binding studies support the hypothesis that the receptor system for IFN-gamma is unrelated to the IFN-alpha/beta system.
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