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  • Title: [The role of ADP-ribosylation processes in the repair of cytogenetic damage in mammalian cells].
    Author: Aptikaeva GF, Ganassi EE.
    Journal: Radiobiologiia; 1985; 25(2):155-8. PubMed ID: 3159034.
    Abstract:
    Nicotinamide (NA) was shown to increase the yield of chromosome aberrations in irradiated Chinese hamster cells. The effect was observed with all doses used (1-4 Gy) and in all phases of the cell cycle; it was maximum as cells transferred from S to G1 phase. The modification of radiation-induced aberrations was more pronounced in the chromatid deletions and in exchanges. The combined action of NA and caffeine showed a synergism. It is assumed that NA inhibits reparation in a different way than caffeine does.
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